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Title: Mapping of the antigenic determinants recognized by monoclonal antibodies against the M2 protein of rabies virus.
identifier: 1106275
description:
epitope description:AIKDLKKPCITLGKAPDLNKAYKSVLSGMNAAKLDPDDVCS
antigen name:Nucleoprotein
host organism:Mus musculus BALB/c
antibody name:MoAb 6, 7, 13, 19, 21
aggregation:
instance of dataset
availability:
available
primaryPublications: 1372139
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1000880
landingPage: http://www.iedb.org/assay/1106275
type:
Literature
publicationVenue:
Virology
dates:
1992
study type: b cell assays
subject species: Rabies virus Nishigahara RCEH
fullName:
K Hiramatsu
K Mifune
K Mannen
A Nishizono
H Kawano
Y Ito
A Kawai
method:
immunoprecipitation
name:
Mapping of the antigenic determinants recognized by monoclonal antibodies against the M2 protein of rabies virus.
description:
Epitope is located in the M2 protein of Rabies virus. The actual sequence was found in a previous paper, Mannen et al (1991) Virus Genes 5:69-73, (PubMed 2017877).
The experiment involved noting the capacity of monoclonal antibodies to precipitate in vitro translation procucts by truncated cDNAs of the M2 gene. The epitope is deduced from truncation analysis, showing binding to certain rabies polypeptides and lack of binding to others. MoAb 6 is IgG2a, while the others are IgG1.

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