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Title: Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus.
identifier: 1186263
description:
epitope description:D315
antigen name:Genome polyprotein
host organism:Mus musculus
antibody name:K2-4F2
aggregation:
instance of dataset
availability:
available
primaryPublications: 2460866
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1000655
landingPage: http://www.iedb.org/assay/1186263
type:
Literature
publicationVenue:
Proc Natl Acad Sci U S A
dates:
1988
study type: b cell assays
subject species: Human hepatitis A virus Hu/Australia/HM175/1976
fullName:
L H Ping
R W Jansen
J T Stapleton
J I Cohen
S M Lemon
method:
biological activity
name:
Identification of an immunodominant antigenic site involving the capsid protein VP3 of hepatitis A virus.
description:
Residue is present on capsid protein VP3.
Escape mutants of antibody K2-4F2 were isolated and sequenced. The S30 strain resistant to K2-4F2 was also resistant to neutralization by antibodies 6A5, 10.09, 1B9, and partially resistant to K3-4C8, K3-2F2, 813, 2D2, 3E1, and B5-B3. This cross-resistance suggests that the epitopes recognized by these antibodies comprise a single functional antigen domain.

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