Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence.

Dataset

identifier:	1212430
description:	epitope description:G53, I55, K166, K217 antigen name:Glycoprotein host organism:Mus musculus BALB/c antibody name:PVK
aggregation:	instance of dataset
availability:	available
primaryPublications:	2446011

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000654
landingPage:	http://www.iedb.org/assay/1212430

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1988

Dimension

study type:	b cell assays
subject species:	Rabies virus CVS

Person

fullName:	C Prehaud P Coulon F LaFay C A Flamand

Data Type

method:	biological activity

Study

name:	Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence.
description:	The sequence in Swissprot is 524 AA in length, with the first 19 AA representing the signal sequence. Mutants at G34,I36, K147 are only partially resistant to neutralization by this mAb. Binding is not seen to be affected by mutations at G34, I 36, K147 and K198. Mutations in AA G34, K147 and K198 resulted in reduced pathogenicity after intramuscular inoculation of the virus in adult mice.The mutant virus resulting from a mutation in K147 was 300 times less pathogenic than CVS.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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