Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates.

Dataset

identifier:	1243604
description:	epitope description:TTLPKGFYAEGSRGG antigen name:Nucleoprotein host organism:Macaca cyclopis
aggregation:	instance of dataset
availability:	available
primaryPublications:	16494977

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001078
landingPage:	http://www.iedb.org/assay/1243604

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2006

Dimension

study type:	b cell assays
subject species:	SARS coronavirus Urbani

Person

fullName:	Shih-Jen Liu Chih-Hsiang Leng Shu-Pei Lien Hsiang-Yun Chi Chiung-Yi Huang Chang-Ling Lin Wei-Cheng Lian Chi-Ju Chen Shie-Liang Hsieh Pele Chong

Data Type

method:	ELISA

Study

name:	Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates.
description:	Peptides derived from the SARS CoV N protein sequence were synthesized as 15-mer fragments with 10 amino acid overlaps that covered the entire length of the N protein of the Urbani. In order to identify immunodominant B cell epitopes within the N protein of SARS CoV, a panel of 80 overlapping 15mer peptides representing the entire protein were screened for reactivity to sera from immunized Formosan macaques. This peptide was found to induce significant reactivity. The authors identified residues 156-175 as an immunodominant epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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