Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates.

Dataset

identifier:	1243733
description:	epitope description:QPLPQRQKKQPTVTL antigen name:Nucleoprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	16494977

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001078
landingPage:	http://www.iedb.org/assay/1243733

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2006

Dimension

study type:	b cell assays
subject species:	SARS coronavirus Urbani

Person

fullName:	Shih-Jen Liu Chih-Hsiang Leng Shu-Pei Lien Hsiang-Yun Chi Chiung-Yi Huang Chang-Ling Lin Wei-Cheng Lian Chi-Ju Chen Shie-Liang Hsieh Pele Chong

Data Type

method:	ELISA

Study

name:	Immunological characterizations of the nucleocapsid protein based SARS vaccine candidates.
description:	Peptides derived from the SARS CoV N protein sequence were synthesized as 15-mer fragments with 10 amino acid overlaps that covered the entire length of the N protein of the Urbani. In order to identify immunodominant B cell epitopes within the N protein of SARS CoV, a panel of 80 overlapping 15mer peptides representing the entire protein were screened for reactivity to sera from 5 human SARS patients. This peptide failed to induce significant reactivity.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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