Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001080 |
| landingPage: |
http://www.iedb.org/assay/1244183 |
| type: |
Literature
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| publicationVenue: |
Vaccine
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| dates: |
2006
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| study type: | b cell assays |
| subject species: | Yersinia pestis 195/P |
| fullName: |
Vinita Tripathi
K T Chitralekha
Anand R Bakshi
Deepak Tomar
R A Deshmukh
M A Baig
D N Rao
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| method: |
in vivo assay
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| name: |
Inducing systemic and mucosal immune responses to B-T construct of F1 antigen of Yersinia pestis in microsphere delivery.
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| description: |
No mice survived 4 days after intraperitoneal challenge with live Y. pestis 50 days after the primary immunization with a construct (B4T1) including this B cell epitope linked to by two G residues to a T helper epitope from the same protein F1, entrapped in a poly-DL-lactide-co-glycolide (PLG) microparticle, which is the same survival seen in non-immunized mice. The protection afforded by the intranasal route of administration when the Th epitope is T1 is the same as with another Th epitope (T2: TGSQDFFVRSIG) or by intramuscular immunization.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
