Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope.

Title:

Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope.

Dataset

identifier:	1244307
description:	epitope description:ASREAKKQVEKALE antigen name:UniProt:A2RGM0 host organism:Mus musculus B10.BR
aggregation:	instance of dataset
availability:	available
primaryPublications:	12034109

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001168
landingPage:	http://www.iedb.org/assay/1244307

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2002

Dimension

study type:	b cell assays
subject species:	Streptococcus pyogenes

Person

fullName:	Colleen Olive Timothy Clair Penny Yarwood Michael F Good

Data Type

method:	in vivo assay

Study

name:	Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope.
description:	Mice immunized with the epitope (peptide) then challenged with Group A Streptococcus were better protected from pharyngeal colonization compared with non-immunized animals; these same animals also had a better a survival percentage at 22 days.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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