Identifying the principal protective antigenic determinants of type A botulinum neurotoxin. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identifying the principal protective antigenic determinants of type A botulinum neurotoxin.

Dataset

identifier:	1244634
description:	epitope description:GTKFIIKKYASGNKDNIVRNNDRVY antigen name:Botulinum neurotoxin type A (UniProt:A5HZZ9) host organism:Mus musculus BALB/c antibody name:4A2-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	9795391

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001274
landingPage:	http://www.iedb.org/assay/1244634

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	1998

Dimension

study type:	b cell assays
subject species:	Clostridium botulinum

Person

fullName:	S Bavari D D Pless E R Torres F J Lebeda M A Olson

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Identifying the principal protective antigenic determinants of type A botulinum neurotoxin.
description:	This peptide was constructed based on a secondary structure prediction algorithm that located highly solvent-exposed residues on Botulinum neurotoxin A. This sequence is located in the C-terminus of the heavy chain. Dissociation rate of the monoclonal antibody previously shown to recognize the C-terminal region of BoNT Hc was determined by SPR.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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