Glycoproteins E2 of the Venezuelan and eastern equine encephalomyelitis viruses contain multiple cross-reactive epitopes.

Title:

Glycoproteins E2 of the Venezuelan and eastern equine encephalomyelitis viruses contain multiple cross-reactive epitopes.

identifier:	1246144
description:	epitope description:K549 antigen name:Structural polyprotein host organism:Mus musculus antibody name:3E11
aggregation:	instance of dataset
availability:	available
primaryPublications:	8973533

study type:	b cell assays
subject species:	Venezuelan equine encephalitis virus (strain TC-83)

fullName:	A V Pereboev I A Razumov V A Svyatchenko V B Loktev

method:	biological activity

name:	Glycoproteins E2 of the Venezuelan and eastern equine encephalomyelitis viruses contain multiple cross-reactive epitopes.
description:	Discontinuous antigenic determinants were revealed for the E2 glycoprotein of VEE and EEE using escape-variant viruses generated by cross-reactive monoclonal antibodies. Discontinuous epitopes were identified using mAbs to generate viral variants capable of escaping neutralization or protection. MAb 3E11 demonstrated binding, neutralizing, hemagglutinin inhibition and protective activity against VEE, as well as EEE.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.