Synthetic peptide vaccine against mucosal colonization by group A streptococci. I. Protection against a heterologous M serotype with shared C repeat region epitopes.

Title:

Synthetic peptide vaccine against mucosal colonization by group A streptococci. I. Protection against a heterologous M serotype with shared C repeat region epitopes.

Dataset

identifier:	1468601
description:	epitope description:LDASREAKKQVEKDLANLTAEL antigen name:UniProt:A2RGM0 host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	1696296

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/966
landingPage:	http://www.iedb.org/assay/1468601

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1990

Dimension

study type:	b cell assays
subject species:	Streptococcus pyogenes serotype M6 strain D471

Person

fullName:	D Bessen V A Fischetti

Data Type

method:	ELISA

Study

name:	Synthetic peptide vaccine against mucosal colonization by group A streptococci. I. Protection against a heterologous M serotype with shared C repeat region epitopes.
description:	Anti-peptide Fab polyclonal antibody fragments bound to heterologous M14 type of S. pyogenes. Also, mice that received intranasal immunizations with a mixture of four synthetic peptides, including this one, from S. pyogenes M6, conjugated to Cholera toxin B subunit (Peptide 240-260: SRKGLRRDLDASREAKKQVEK, Peptide 248-269: LDASREAKKQVEKDLANLTAEL, Peptide 256-277: KQVEKDLANLTAELDKVKEEKQ, and Peptide 272-292: VKEEKQISDASRQGLRRDLDA) displayed substantially lower levels of infection and death after viral challenge.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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