Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc.

Title:

Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc.

identifier:	1267384
description:	epitope description:YESNHLIDLSRYASKINIG antigen name:Botulinum neurotoxin type A (UniProt:A5HZZ9) host organism:Mus musculus SJL
aggregation:	instance of dataset
availability:	available
primaryPublications:	9541456

study type:	b cell assays
subject species:	Clostridium botulinum

fullName:	M Oshima J L Middlebrook M Z Atassi

method:	radio immuno assay (RIA)

name:	Antibodies and T cells against synthetic peptides of the C-terminal domain (Hc) of botulinum neurotoxin type A and their cross-reaction with Hc.
description:	Peptide previously identified as harboring antibody epitope/s recognized in the response against the H_c subunit of BoNT/A in SJL and BALB/c mice. When SJL mice were immunized with an equimolar mixture of peptides, including this one, that are said to contain T and/or B cell epitopes for mice immunized with H_c subunit of BoNT/A, significant responses are obtained against this peptide. No responses had been obtained when immunized with this peptide alone, suggesting Ab production to this peptide is modulated by help and inter-site influences of the cellular responses against the mixture constituent peptides.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.