Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides.

Title:

Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides.

identifier:	1270709
description:	epitope description:NNWPCLNETCPTKG host organism:Homo sapiens antibody name:80R
aggregation:	instance of dataset
availability:	available
primaryPublications:	16630634

study type:	b cell assays
subject species:

fullName:	Natalia Tarnovitski Leslie J Matthews Jianhua Sui Jonathan M Gershoni Wayne A Marasco

method:	ELISA

name:	Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides.
description:	This peptide was isolated from a phage display library containing peptides with cysteine-constrained loops using a neutralizing anti-SARS spike protein monoclonal antibody. The human recombinant mAb used in this study has previously been shown to be a potent SARS-CoV-neutralizing mAb in vitro and in vivo. In this study, the mAb was panned against a phage display library, and specific bound clones were sequenced. The derived peptides were subsequently used for computational predictions to map the neutralizing epitope.

name:	iedb
homePage:	http://www.iedb.org

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