Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1001341 |
| landingPage: |
http://www.iedb.org/assay/1270835 |
| type: |
Literature
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| publicationVenue: |
Int J Med Microbiol
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| dates: |
2006
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| study type: | b cell assays |
| subject species: |
| fullName: |
Elena Goncharova
Evgeny Ryzhikov
Vasily Poryvaev
Leonid Bulychev
Nikolay Karpyshev
Amir Maksyutov
Alexander B Ryzhikov
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| method: |
in vivo assay
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| name: |
Intranasal immunization with inactivated tick-borne encephalitis virus and the antigenic peptide 89-119 protects mice against intraperitoneal challenge.
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| description: |
This peptide was selected by comparison of human proteins to the tick-borne encephalitis virus E protein based on its low frequency of antigenic similarity to human proteins. It mimicks the naturally-occurring conservative region 89-119 of the tick-borne encephalitis virus E protein, with an exact amino acid sequence as this region except for an alanine substitution at position 17.
Intranasal immunization with the antigenic peptide incorporated into nanoparticles was shown to induce a TBE-specific humoral immunity, and intraperitoneal challenge of mice with TBE virus at a dose of 100 LD50 2 weeks after thefourth immunization resulted in a 58% survival rate.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
