Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi.

Dataset

identifier:	1271083
description:	epitope description:VNSRCEQI antigen name:60 kDa chaperonin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	7691753

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1000587
landingPage:	http://www.iedb.org/assay/1271083

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	1993

Dimension

study type:	b cell assays
subject species:	Orientia tsutsugamushi

Person

fullName:	R Lachumanan S Devi Y M Cheong S J Rodda

Data Type

method:	ELISA

Study

name:	Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi.
description:	This peptide is recognized with significantly higher reactivity in 9 out of 9 scrub typhus patients serum than in normal serum. Also, it is recognized with significantly lower reactivity in other febrile illnesses - that share geographic distribution with scrub typhus - such as dengue, leptospirosis, typhoid fever and malaria. The isotype specificicity of the reactivity is shown to be mainly of IgM type in 2 out of 3 selected acute scrub typhus patients, while the 3rd has similar IgG and IgM reactivity. Low specific IgA reactivity is seen.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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