Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.

Title:

Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.

identifier:	1271271
description:	epitope description:GATFQVEVPG antigen name:Heat-labile enterotoxin B chain host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	8606092

study type:	b cell assays
subject species:	Escherichia coli ETEC H10407

fullName:	I Takahashi H Kiyono R J Jackson K Fujihashi H F Staats S Hamada J D Clements K L Bost J R McGhee

method:	ELISA

name:	Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
description:	The immunogenicity of peptide 26-45 was tested in H-2d mice immunized with this peptide alone or conjugated to ovalbumin (OVA). LT-B-specific IgA was generated following p26-45 immunization. However, this response was nearly half that observed when using p26-45 as antigen. Positive reactivity of IgA to LT-B was confirmed by western blot analysis (Figure 7). Mice immunized with the peptide-OVA conjugate showed similar responsiveness. Three different mouse strains (B10.D2, B10, and B10.BR) were immunized with similar results.

name:	iedb
homePage:	http://www.iedb.org

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