Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001359 |
| landingPage: |
http://www.iedb.org/assay/1271878 |
| type: |
Literature
|
| publicationVenue: |
Vaccine
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Hong Kong/483/1997(H5N1)) |
| fullName: |
William A Ernst
Hyung J Kim
Terrence M Tumpey
Airan D A Jansen
Wendy Tai
Donald V Cramer
Jill P Adler-Moore
Gary Fujii
|
| method: |
in vivo assay
|
| name: |
Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines.
|
| description: |
This peptide corresponds to the first 24 residues of matrix protein 2 as found in several strains of the H5N1 subtype of Influenza A virus.
A significant reduction in viral titers in the lungs is seen5 days after challenge with 10 LD50, in mice immunized with this peptide as a fusion protein with a proprietary hydrophobic domain (HD) encapsulated in liposomes, as compared with the response obtained in mice immunized with control liposomes without fusion protein.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |