Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue.

Title:

Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue.

identifier:	1273010
description:	epitope description:CITQYERESQAYY antigen name:Major prion protein host organism:Mus musculus BALB/c antibody name:V5B2
aggregation:	instance of dataset
availability:	available
primaryPublications:	14593100

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Vladka Curin Serbec Mara Bresjanac Mara Popovic Katrina Pretnar Hartman Vesna Galvani Ruth Rupreht Maja Cernilec Tanja Vranac Iva Hafner Roman Jerala

method:	western blot

name:	Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue.
description:	The monoclonal antibody (V5B2) did not react on Western Blot analysis with extracts from Creutzfeldt-Jacob's disease (CJD) and non-CJD brains. In further assays, the mAb was found not to react with any form of recombinant prion protein. The authors conclude that the C-terminal part of prion protein in diseases-associated pathological prion isoform aggregates forms a structural epitope whose conformation is distinct from that of cellular prion protein.

name:	iedb
homePage:	http://www.iedb.org

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