Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides.

Title:

Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides.

identifier:	1273314
description:	epitope description:CGFADLMGYIPLVGAPLGGAARALA antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15063567

study type:	b cell assays
subject species:	Hepatitis C virus

fullName:	Bettina Langhans Ingrid Braunschweiger Susann Schweitzer Tilman Sauerbruch Ulrich Spengler

method:	ELISPOT

name:	Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides.
description:	Hepatitis C virus (HCV)-specific antibody producing B lymphocytes were induced in vitro with a HCV-derived lipopeptide containing a T helper cell epitope. Purified B cells and autologous T helper cells from healthy donors were cultured in vitro with the lipopeptide, and the number of IgG, IgA, and IgM antibody-producing B cells after in vitro immunization was quantified by ELISPOT. The lipopeptide was formed by coupling the peptide to a lipid tail consisting of three palmitoylacid chains. A response was also found to the lipidated peptide in 1 of 14 donors.

name:	iedb
homePage:	http://www.iedb.org

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