Selective and efficient immunoprecipitation of the disease-associated form of the prion protein can be mediated by nonspecific interactions between monoclonal antibodies and scrapie-associated fibrils.

Title:

Dataset

identifier:	1276471
description:	epitope description:DYEDRYYREN antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:SAF-53, SAF-61
aggregation:	instance of dataset
availability:	available
primaryPublications:	15140886

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001492
landingPage:	http://www.iedb.org/assay/1276471

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2004

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Nathalie Morel Sté phanie Simon Yveline Frobert Hervé Volland Chantal Mourton-Gilles Alessandro Negro Maria Catia Sorgato Christophe Cré minon Jacques Grassi

Data Type

method:	ELISA

Study

name:	Selective and efficient immunoprecipitation of the disease-associated form of the prion protein can be mediated by nonspecific interactions between monoclonal antibodies and scrapie-associated fibrils.
description:	The human, sheep, and bovine sequences are identical in this region. The epitope of MAbs SAF-53 and SAF-61 was deduced based on antibody binding to 12-mer peptides (frameshifted by one residue) synthesized on a cellulose membrane.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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