Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine.

Title:

Dataset

identifier:	1276862
description:	epitope description:D429, R441, E452, D454 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:S6, S37, S50
aggregation:	instance of dataset
availability:	available
primaryPublications:	16725238

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001361
landingPage:	http://www.iedb.org/assay/1276862

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2006

Dimension

study type:	b cell assays
subject species:	SARS coronavirus

Person

fullName:	Yuxian He Jingjing Li Lanying Du Xuxia Yan Guangan Hu Yusen Zhou Shibo Jiang

Data Type

method:	biological activity

Study

name:	Identification and characterization of novel neutralizing epitopes in the receptor-binding domain of SARS-CoV spike protein: revealing the critical antigenic determinants in inactivated SARS-CoV vaccine.
description:	The amino acids and positions were identified by single point mutation in the receptor-binding domain of SARS coronavirus. Alanine-substitution of the these critical residues significantly hampered the binding of monoclonal antibodies (S6, S37, S50) to mutant viruses. The monoclonal antibodies exhibited potent neutralization of SARS pseudoviruses.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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