Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1277207 |
| description: |
epitope description:RLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL
antigen name:Botulinum neurotoxin type A (UniProt:A5HZZ9)
host organism:Homo sapiens
antibody name:3D12
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
11858873 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/769 |
| landingPage: |
http://www.iedb.org/assay/1277207 |
| type: |
Literature
|
| publicationVenue: |
Vaccine
|
| dates: |
2002
|
| study type: | b cell assays |
| subject species: | Clostridium botulinum |
| fullName: |
Peter Amersdorfer
Cindy Wong
Theresa Smith
Steven Chen
Sharad Deshpande
Robert Sheridan
James D Marks
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries.
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| description: |
Affinity for the Hc domain was determined for a purified scFv fragment selected from a phage display library derived from a pentavalent toxoid-immunized donor. This scFv is also shown to bind Hc domain in ELISA and to have neutralizing activity of the holotoxin in an in vitro mouse hemidiafragm assay. 2 other scFv were found to be clonally related to this one by sequence analysis and to bind to the same or overlapping epitopes (referred to as cluster I) by competition for reactivity on the SPR chip.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
