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Title: Identification of an antigenic epitope in Helicobacter pylori urease that induces neutralizing antibody production.
identifier: 1277216
description:
epitope description:SIKEDVQF
antigen name:Urease subunit beta
host organism:Oryctolagus cuniculus
aggregation:
instance of dataset
availability:
available
primaryPublications: 11598027
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1001613
landingPage: http://www.iedb.org/assay/1277216
type:
Literature
publicationVenue:
Infect Immun
dates:
2001
study type: b cell assays
subject species: Helicobacter pylori 26695
fullName:
K Hirota
K Nagata
Y Norose
S Futagami
Y Nakagawa
H Senpuku
M Kobayashi
H Takahashi
method:
ELISA
name:
Identification of an antigenic epitope in Helicobacter pylori urease that induces neutralizing antibody production.
description:
This is a deduced epitope identified by truncation analysis.
This assay was performed using truncated and substitued synthetic peptides of UB-33 in order to identify the minimal epitope (SIKEDVQF) in the L2 protein. Lysine at position 329 was critical residue for the biding and neutralizing activity of antibody L2.

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