Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1277798 |
| description: |
epitope description:V121, G122, G123, L124, G125, G126, Y127, M128, L129, G130, S131, A132, M133, S134, Q218, K219, E220, S221
antigen name:Major prion protein
host organism:Mus musculus PrP null
antibody name:POM4, POM10, POM19
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
16297838 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001581 |
| landingPage: |
http://www.iedb.org/assay/1277798 |
| type: |
Literature
|
| publicationVenue: |
Lancet Neurol
|
| dates: |
2005
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| study type: | b cell assays |
| subject species: | Mus musculus |
| fullName: |
Magdalini Polymenidou
Katharina Stoeck
Markus Glatzel
Martin Vey
Anne Bellon
Adriano Aguzzi
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| method: |
antigen inhibition
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| name: |
Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease.
|
| description: |
Epitope mapping was performed using a library of 100 overlapping dodecamers, shifted by 2 amino acids, spanning residues 23-232 of the mature mouse prion protein. The epitope of MAb POM4, POM10, and POM19 was deduced to include residues 121-134 and 218-221 based on the ability of dodecamers to inhibit binding of the antibody to mouse PrP(23-230).
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
