Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease.

Dataset

identifier:	1277806
description:	epitope description:QPHGGSW antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:POM2, POM12
aggregation:	instance of dataset
availability:	available
primaryPublications:	16297838

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001581
landingPage:	http://www.iedb.org/assay/1277806

Publication

type:	Literature
publicationVenue:	Lancet Neurol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Magdalini Polymenidou Katharina Stoeck Markus Glatzel Martin Vey Anne Bellon Adriano Aguzzi

Data Type

method:	antigen inhibition

Study

name:	Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease.
description:	The epitope is repeated exactly at residues 74-80 and repeated at residues 58-64 and 82-88 with a Ser to Gly substitution at position 6. Epitope mapping was performed using a library of 100 overlapping dodecamers, shifted by 2 amino acids, spanning residues 23-232 of the mature mouse prion protein. The epitope of MAbs POM2 and POM12 was deduced based on the ability of dodecamers to inhibit binding of the antibody to mouse PrP(23-230). MAbs POM2 and POM12 bound to peptides containing the repetitive epitope found at residues 58-64, 66-72, 74-80, and 82-88.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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