Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters.

Title:

Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters.

Dataset

identifier:	1278552
description:	epitope description:AESPKKP antigen name:Outer surface protein C host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	15939749

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001719
landingPage:	http://www.iedb.org/assay/1278552

Publication

type:	Literature
publicationVenue:	Clin Diagn Lab Immunol
dates:	2005

Dimension

study type:	b cell assays
subject species:	Borreliella burgdorferi

Person

fullName:	Steven D Lovrich Dean A Jobe Ronald F Schell Steven M Callister

Data Type

method:	western blot

Study

name:	Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters.
description:	The amino acid sequence of OspC C7 of B. burgdorferi sensu stricto (50772) was obtained from Jobe DA et al. Clin Diag Lab Immunol 2003 10:573. Early lyme disease patient sera was reacted against B. burgdorferi before and after adsorptions with the full OspC protein, the C16 fragment and the C7 fragment to determine the ability of these peptides to block reactivity. Binding to the C16 and C7 OspC fragments almost completely removed the antibodies detected by Western blot analysis.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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