Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1001816 |
| landingPage: |
http://www.iedb.org/assay/1289353 |
| type: |
Literature
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| publicationVenue: |
J Clin Microbiol
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| dates: |
1993
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| study type: | b cell assays |
| subject species: | Hepatitis C virus subtype 1a |
| fullName: |
P Simmonds
K A Rose
S Graham
S W Chan
F McOmish
B C Dow
E A Follett
P L Yap
H Marsden
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| method: |
ELISA
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| name: |
Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3.
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| description: |
This peptide was synthesized as part of panel of overlapping 9-mers representing the consensus sequence of the NS4 of HCV 1a subtypes.
The reactivities of representative anti-HCV positive plasma samples were tested against overlapping peptides corresponding to sequences within the NS4 region of HCV-1. The authors identified two major antigenic regions, aa1691-1708 and aa1710-1728. The investigation of cross-reactivity between HCV genotypes (1a, 1b, 2 and 3) showed that reactivity to heterologous peptides was variable and generally weaker than that to homologous type peptides.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
