Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001816 |
| landingPage: |
http://www.iedb.org/assay/1289629 |
| type: |
Literature
|
| publicationVenue: |
J Clin Microbiol
|
| dates: |
1993
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus subtype 2b |
| fullName: |
P Simmonds
K A Rose
S Graham
S W Chan
F McOmish
B C Dow
E A Follett
P L Yap
H Marsden
|
| method: |
ELISA
|
| name: |
Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3.
|
| description: |
This peptide was synthesized as part of panel of overlapping 9-mers representing the consensus sequence of the NS4 of HCV 2b subtypes.
The reactivities of representative anti-HCV positive plasma samples were tested against overlapping peptides corresponding to sequences within the NS4 region of HCV-1. The authors identified two major antigenic regions, aa1691-1708 and aa1710-1728. The investigation of cross-reactivity between HCV genotypes (1a, 1b, 2 and 3) showed that reactivity to heterologous peptides was variable and generally weaker than that to homologous type peptides.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
