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Title: Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
identifier: 1289660
description:
epitope description:TTHTVGGSVARQVHSLTGLFSPGPQQK
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 9649423
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1001824
landingPage: http://www.iedb.org/assay/1289660
type:
Literature
publicationVenue:
EMBO J
dates:
1998
study type: b cell assays
subject species:
fullName:
G Puntoriero
A Meola
A Lahm
S Zucchelli
B B Ercole
R
M Pezzanera
M U Mondelli
R Cortese
A Tramontano
G Galfre'
A Nicosia
method:
ELISA
name:
Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
description:
This consensus mimotope is derived from 234 variants of HCV E2 glycoprotein at N-terminal hypervariable region 1 (27 aa) by 2-cycle selection from constructed phage library with 20 HCV infected sera covering various geno-/sero-type.
Average binding values from two independent experiments greater than 3 folds of wild type phages are considered as positive. After two rounds selection with two sets of HCV positive sera, this epitope was recognized by at least 60% patient sera, but not healthy donor sera.

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