Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1001847 |
| landingPage: |
http://www.iedb.org/assay/1293895 |
| type: |
Literature
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| publicationVenue: |
Immunol Invest
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| dates: |
2002
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| study type: | b cell assays |
| subject species: | Helicobacter pylori |
| fullName: |
Kersti Klaamas
Oleg Kurtenkov
Kate Rittenhouse-Olson
Vadim Brjalin
Ljudmila Miljukhina
Ljudmila Shljapnikova
Lars Engstrand
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| method: |
ELISA
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| name: |
Expression of tumor-associated Thomsen-Friedenreich antigen (T Ag) in Helicobacter pylori and modulation of T Ag specific immune response in infected individuals.
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| description: |
The T antigen (B-D-Galp-(1-3)-a-D-GalNacp) is the carbohydrate moiety in glycoprotein(s) present in human carcinomas. In Helicobacter pylori extracts the T antigen is detected in ~68 and ~58 kDa protein bands in a western blot.
Anti-epitope antibodies were found in sera of H. pylori-seropositive as well as seronegative blood donors. A lower titre of anti-epitope antibodies was found in gastric cancer patients (both H. pylori-seropositive and negative) compared with blood donors, but for these patients a higher titre of anti-epitope antibodies was found in the H. pylori seropositives compared with seronegatives. In blood donors, the level of epitope-specific antibodies correlated positively with anti-H. pylori antibody level; in contrast, no correlation between epitope-specific and anti-H. pylori antibody levels were found in gastric cancer patients (H. pylori-seropositive or negative).
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
