Immunological Data Discovery Index
Advanced Search
  1. << Go Back
Title: Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
identifier: 1296890
description:
epitope description:QTRTVGGQMGHGVRGLTSLFSAGSARN
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 9649423
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1001824
landingPage: http://www.iedb.org/assay/1296890
type:
Literature
publicationVenue:
EMBO J
dates:
1998
study type: b cell assays
subject species: Hepatitis C virus
fullName:
G Puntoriero
A Meola
A Lahm
S Zucchelli
B B Ercole
R
M Pezzanera
M U Mondelli
R Cortese
A Tramontano
G Galfre'
A Nicosia
method:
ELISA
name:
Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
description:
The epitope was one of 40 homogeneously distributed sequences selected by principle component analysis from a set of 234 natural HCV hypervariable region 1 matching residues 384-411 of BK strain.
Sera (dilution 1:100) from mice immunized with the multiple antigenic peptide (MAP) of mimotope N5 (sequence: TTTTTGGVQGHTTRGLVRLFSLGSKQN) were tested by ELISA with the epitope synthesized as MAP. Positive reactivity is that when average values from two independent experiments were greater than 3-fold of the background values of two unrelated peptides.

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.

ImmuneData is supported by the NIAID, Grant HHSN272201700019C. Privacy

ImmuneData is developed by TechWave International, Inc. and UT Health Science Center at Houston