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Title: Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
identifier: 1312193
description:
epitope description:GTHTIGGSQAQQANRFVSMFSRGPSQK
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 9649423
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1001824
landingPage: http://www.iedb.org/assay/1312193
type:
Literature
publicationVenue:
EMBO J
dates:
1998
study type: b cell assays
subject species: Hepatitis C virus
fullName:
G Puntoriero
A Meola
A Lahm
S Zucchelli
B B Ercole
R
M Pezzanera
M U Mondelli
R Cortese
A Tramontano
G Galfre'
A Nicosia
method:
ELISA
name:
Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
description:
The epitope was one of 40 homogeneously distributed sequences selected by principle component analysis from a set of 234 natural HCV hypervariable region 1 matching residues 384-411 of BK strain.
Sera (dilution 1:100) from mice immunized with the multiple antigenic peptide (MAP) of mimotope R9 (sequence: QTTVVGGSQSHTVRGLTSLFSPGASQN) were tested by ELISA with the epitope synthesized as MAP. Positive reactivity is that when average values from two independent experiments were greater than 3-fold of the background values of two unrelated peptides.

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