Comparative characterization of antigenic epitopes in the immunodominant region of the protein encoded by open reading frame 3 in Burmese and Mexican strains of hepatitis E virus.

Title:

Comparative characterization of antigenic epitopes in the immunodominant region of the protein encoded by open reading frame 3 in Burmese and Mexican strains of hepatitis E virus.

Dataset

identifier:	1314473
description:	epitope description:PLGEIR antigen name:Protein ORF3 host organism:Homo sapiens antibody name:anti-HEV (strain Mexico)
aggregation:	instance of dataset
availability:	available
primaryPublications:	8126461

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001974
landingPage:	http://www.iedb.org/assay/1314473

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	1994

Dimension

study type:	b cell assays
subject species:	Hepatitis E virus (strain Mexico)

Person

fullName:	Khudyakov YuE N S Khudyakova D L Jue T W Wells N Padhya H A Fields

Data Type

method:	ELISA

Study

name:	Comparative characterization of antigenic epitopes in the immunodominant region of the protein encoded by open reading frame 3 in Burmese and Mexican strains of hepatitis E virus.
description:	The sequence is from the C-terminal region of the HEV ORF 3 protein. Human anti-HEV sera from an outbreak in Mexico in 1986 were assayed against a panel of overlapping hexamer sequences covering residues 91-123 of the ORF 3 protein of HEV strain Mexico. A Lys residue was added to the N terminus and 2 Gly residue were added to the C terminus of the hexamers to improve solubility and plate adsorption. Less than 10% of anti-HEV(M) sera (n = 14) reacted with the epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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