Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1001927 |
| landingPage: |
http://www.iedb.org/assay/1313199 |
| type: |
Literature
|
| publicationVenue: |
Virology
|
| dates: |
1996
|
| study type: | b cell assays |
| subject species: | Human herpesvirus 6 (strain Uganda-1102) |
| fullName: |
K
Y Isegawa
K Yamanishi
|
| method: |
immunoprecipitation
|
| name: |
Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6).
|
| description: |
This amino acid was found to be a key residue for monoclonal antibody reactivity to Human herpesvirus 6A strain U1102.
To determine the amino acid residue(s) responsible for the HHV-6A-specific reactivity with the monoclonal antibody, the neutralization site was mapped to amino acids 335-395 with truncated translation products of glycoprotein B of HHV-6A. Amino acid comparison between HHV-6A and 6B in this region revealed five amino acids that are HHV-6A-specific. Point mutations were introduced at those amino acids, and reactivity with mutagenized glycoprotein B suggested that the Asn residue at position 347 of HHV-6A strain U1102 was involved in recognition.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
