Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1001777 |
| landingPage: |
http://www.iedb.org/assay/1314184 |
| type: |
Literature
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| publicationVenue: |
Clin Exp Immunol
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| dates: |
1994
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| study type: | b cell assays |
| subject species: | Pan troglodytes |
| fullName: |
Z X Zhang
M Chen
K Wallhagen
J Trojnar
L O Magnius
B Wahren
M Sä
llberg
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| method: |
ELISA
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| name: |
Molecular basis for antibody cross-reactivity between the hepatitis C virus core protein and the host-derived GOR protein.
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| description: |
Twenty-nine of 60 sera positive for anti-HCV reacted with the epitope. None of 36 anti-HCV negative sera reacted with the epitope. No HCV serotype was significantly correlated with reactivity to the epitope. Binding of 24 of the 29 anti-GOR-positive sera was inhibited by the epitope. Eleven of the 24 GOR-reactive sera were more efficiently inhibited by HCV core 1-18 than the epitope and the other 13 sera were equally or more efficiently inhibited by the epitope. Alanine substitutions covering HCV core residues 9-17 showed that Lys 10, Lys 12, Asn 14 and Asn 16 are the four most essential residues for binding of anti-GOR reactivity and are almost completely conserved between different strains of HCV core and GOR protein. Thus HCV is the inferred immunogen that elicits anti-GOR reactivity due to cross-reaction.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
