Synthetic peptide immunogens elicit polyclonal and monoclonal antibodies specific for linear epitopes in the D motifs of Staphylococcus aureus fibronectin-binding protein, which are composed of amino acids that are essential for fibronectin binding.

Title:

Dataset

identifier:	1315261
description:	epitope description:QGGNIVDIDFDSVP antigen name:Fibronectin-binding protein A host organism:Oryctolagus cuniculus New Zealand White
aggregation:	instance of dataset
availability:	available
primaryPublications:	10678920

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001988
landingPage:	http://www.iedb.org/assay/1315261

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2000

Dimension

study type:	b cell assays
subject species:	Staphylococcus aureus

Person

fullName:	M Huesca Q Sun R Peralta G M Shivji D N Sauder M J McGavin

Data Type

method:	biological activity

Study

name:	Synthetic peptide immunogens elicit polyclonal and monoclonal antibodies specific for linear epitopes in the D motifs of Staphylococcus aureus fibronectin-binding protein, which are composed of amino acids that are essential for fibronectin binding.
description:	Antibodies inhibited fibronectin binding to tandem D1-2 motif-containing , but not D1-3 nor D3 motif-containing GST fusion protein coated on plates. However, no inhibition of binding to the D1-2 fusion protein was observed when finbronectin coated on plates. Greater inhibition of finbronectin binding to D1-3 motif containing GST fusion protein coated on plates was observed, but not S. aureus binding to coated fibronectin nor keratinocyte ECM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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