An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

Title:

Dataset

identifier:	1315561
description:	epitope description:SQWNKPSKPKTN antigen name:Major prion protein host organism:Oryctolagus cuniculus New Zealand White antibody name:anti-PrP 95-108
aggregation:	instance of dataset
availability:	available
primaryPublications:	9626045

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002009
landingPage:	http://www.iedb.org/assay/1315561

Publication

type:	Literature
publicationVenue:	Am J Pathol
dates:	1998

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	P Piccardo J P Langeveld A F Hill S R Dlouhy K Young G Giaccone G Rossi M Bugiani O Bugiani R H Meloen J Collinge F Tagliavini B Ghetti

Data Type

method:	ELISA

Study

name:	An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.
description:	Anti-human PrP95-108 was tested against overlapping dodecapeptides spanning the entire murine PrP sequence. The antiserum reacted optimally to peptide 99-110 (NKPSKPKTNLKH). The authors deduce the cross-reactive epitope shared between species (human, ovine, bovine, hamster, and murine) to be NKPSKPKTN.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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