T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.

Title:

T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.

Dataset

identifier:	1315570
description:	epitope description:N-acetyl-D-galactosamine antigen name:polysaccharide host organism:Mus musculus BALB/c antibody name:10D4-A9, 2D6-B1, 16B2-A1, 14G2-B12, 11C6-E3 and 6G14-F6
aggregation:	instance of dataset
availability:	available
primaryPublications:	10992488

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001998
landingPage:	http://www.iedb.org/assay/1315570

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2000

Dimension

study type:	b cell assays
subject species:	Streptococcus sp. 'group A'

Person

fullName:	S Malkiel L Liao M W Cunningham B Diamond

Data Type

method:	ELISA

Study

name:	T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.
description:	N-acetyl-glucosamine (GlcNAc) MAb 10D4-A9(IgG2a), 2D6-B1(IgG2b), 16B2-A1(IgG2b), 14G2-B12(IgG2b), 11C6-E3(IgG2b) and 6G14-F6(IgM) all reacted to epitope conjugated BSA (50:1 molar ratio), cardiac myosin and keratin protein. MAb 14G2-B12 and 6G14-F6 also cross-reacted with ssDNA and actin, respectively.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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