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Title: Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus.
identifier: 1324032
description:
epitope description:VLYQEFDE
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
antibody name:3F11, 3F12
aggregation:
instance of dataset
availability:
available
primaryPublications: 12095709
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1001922
landingPage: http://www.iedb.org/assay/1324032
type:
Literature
publicationVenue:
Immunol Lett
dates:
2002
study type: b cell assays
subject species: Hepatitis C virus subtype 1b
fullName:
O V Masalova
E I Lakina
A G Abdulmedzhidova
S N Atanadze
Yu A Semiletov
T V Shkurko
A N Burkov
T I Ulanova
V K Pimenov
V V Novikov
Yu E Khudyakov
H Fields
A A Kushch
method:
ELISA
name:
Characterization of monoclonal antibodies and epitope mapping of the NS4 protein of hepatitis C virus.
description:
The sequence is from the NS4 protein.
The authors deduced that MAbs 3F11 and 3F12 recognize the epitope based on their reactivity with a panel of 33 overlapping peptides covering residues 1683-1750 of the NS4 protein from HCV subtypes 1a, 1b, 2a, 2b, 2c, 3a, 4, 5, and 6. The MAbs reacted strongly with the peptide residues 1689-1708 from genotype 3a. The epitope is genotype-independent and recognized in HCV genotypes 1, 2, and 3.

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