Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1001975 |
| landingPage: |
http://www.iedb.org/assay/1317974 |
| type: |
Literature
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| publicationVenue: |
Clin Diagn Lab Immunol
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| dates: |
1994
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| study type: | b cell assays |
| subject species: | Hepatitis C virus subtype 1b |
| fullName: |
J A Quiroga
J Martin
M Pernas
M Pardo
M Herrero
I Castillo
J Bartolome
V Carreñ
o
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| method: |
ELISA
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| name: |
Evidence of subtype-specific antibodies to antigenic epitopes in the NS5 region of hepatitis C virus in the circulation of patients with chronic hepatitis C.
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| description: |
The sequence is in the NS5 region.
The antigenicity of the NS5 region with anti-HCV-positive sera was assessed using a set of 199 overlapping hexapeptides spanning residues 2530-2733 of HCV subtype 1b. The epitope was deduced to be one of six regions with significant reactivity and was designated region III. The sequence of this region varies between subtypes 1a, 1b, 2a, and 2b. Sixty-one pecent (92 of 150) of patients reacted with the epitope from at least one of four subtype 1b isolates and 27% (40 of 150) reacted with the epitope from a subtype 1a isolate.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
