Protective and nonprotective epitopes from amino termini of M proteins from Australian aboriginal isolates and reference strains of group A streptococci.

Title:

Protective and nonprotective epitopes from amino termini of M proteins from Australian aboriginal isolates and reference strains of group A streptococci.

Dataset

identifier:	1318244
description:	epitope description:TEVKAAGQSAPKGTNVSADL antigen name:UniProt:A2RGM0 host organism:Mus musculus B10.BR
aggregation:	instance of dataset
availability:	available
primaryPublications:	11083769

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002002
landingPage:	http://www.iedb.org/assay/1318244

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2000

Dimension

study type:	b cell assays
subject species:	Streptococcus pyogenes serotype M11

Person

fullName:	E R Brandt W A Relf R I Hobb M F Good

Data Type

method:	biological activity

Study

name:	Protective and nonprotective epitopes from amino termini of M proteins from Australian aboriginal isolates and reference strains of group A streptococci.
description:	Cysteine residue is added to the C-terminal of peptide for conjugation to tetanus toxoid. Opsonization activity of antisera against non-homologous isolate/strain was tested. The epitope specific antisera had strong/moderate opsonic activity against GAS isolates BSA10, 2032, 2040 and 2034, weak killing to isolateY530S, but no killing for isolate 88/30.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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