Use of overlapping synthetic peptides to characterize samples from blood donors with indeterminate results to hepatitis C virus core antigen.

Title:

Use of overlapping synthetic peptides to characterize samples from blood donors with indeterminate results to hepatitis C virus core antigen.

identifier:	1318446
description:	epitope description:KARRPEGRTWAQPGY antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	9745151

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1a

fullName:	P Leó n J A Ló pez C Elola S R Lee M Calmann J M Echevarrí a

method:	ELISA

name:	Use of overlapping synthetic peptides to characterize samples from blood donors with indeterminate results to hepatitis C virus core antigen.
description:	Single serum samples from 87 blood donors were screened for reactivity to overlapping peptides spanning c22-3. Among samples positive or indeterminant for core in RIBA-3, the peptide reactivities concentrated mainly in the N-terminal half of the molecule (the first five overlapping peptides) and secondarily in the central portion represented by peptides 6, 7, and 8. By contrast, reactivity to the first peptide was clearly dominant among the RIBA-3-negative samples, with just a small participation of other epitopes (mainly peptides 5 and 6).

name:	iedb
homePage:	http://www.iedb.org

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