Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology.

Title:

Dataset

identifier:	1318475
description:	epitope description:ASREAKKQVEKALE antigen name:UniProt:A2RGM0 host organism:Mus musculus B10.BR
aggregation:	instance of dataset
availability:	available
primaryPublications:	11940119

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001844
landingPage:	http://www.iedb.org/assay/1318475

Publication

type:	Literature
publicationVenue:	Immunol Cell Biol
dates:	2002

Dimension

study type:	b cell assays
subject species:	Streptococcus pyogenes

Person

fullName:	Wendy A Hayman Istvan Toth Nicholas Flinn Martin Scanlon Michael F Good

Data Type

method:	ELISA

Study

name:	Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology.
description:	The epitope was identified by overlapping peptides analysis using fragments of the immunogen with extra amino acids added to both N- and C- termini of these segments (to maintain the overall helicity of the structure). It was demonstrated that the epitope is the immunodominant part of the immunogen. Sera from immunized mice were positive by ELISA when the immunogen or fragments of the immunogen were used as assay antigens.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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