Evidence of subtype-specific antibodies to antigenic epitopes in the NS5 region of hepatitis C virus in the circulation of patients with chronic hepatitis C.

Title:

Evidence of subtype-specific antibodies to antigenic epitopes in the NS5 region of hepatitis C virus in the circulation of patients with chronic hepatitis C.

Dataset

identifier:	1318658
description:	epitope description:DVVTKLPLAVMG antigen name:Genome polyprotein host organism:Homo sapiens antibody name:HCV-positive sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	8556499

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1001975
landingPage:	http://www.iedb.org/assay/1318658

Publication

type:	Literature
publicationVenue:	Clin Diagn Lab Immunol
dates:	1994

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1a

Person

fullName:	J A Quiroga J Martin M Pernas M Pardo M Herrero I Castillo J Bartolome V Carreñ o

Data Type

method:	ELISA

Study

name:	Evidence of subtype-specific antibodies to antigenic epitopes in the NS5 region of hepatitis C virus in the circulation of patients with chronic hepatitis C.
description:	The sequence is in the NS5 region. The antigenicity of the NS5 region was assessed using a set of 199 overlapping hexapeptides spanning residues 2530-2733 of HCV subtype 1b. Six regions with significant reactivity were identified and the epitope is the subtype 1a homologue of region II. Nineteen percent (29 0f 150) anti-HCV-positive sera reacted with the epitope and/or the homologous peptide from subtype 1a isolate H which differs at one position.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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