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identifier: 1320500
description:
epitope description:VPHPNIEEVALSTTGE
antigen name:Genome polyprotein
host organism:Mus musculus C57BL/10 X DBA/2
antibody name:anti-rNS3
aggregation:
instance of dataset
availability:
available
primaryPublications: 8922465
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1002071
landingPage: http://www.iedb.org/assay/1320500
type:
Literature
publicationVenue:
J Gen Virol
dates:
1996
study type: b cell assays
subject species: Hepatitis C virus subtype 1a
fullName:
M Sä
llberg
Z X Zhang
M Chen
L Jin
A Birkett
D L Peterson
D R Milich
method:
ELISA
name:
Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein.
description:
The sequence is from the NS3 protein.
Sera from NS3-immunized mice reacted with rNS3 (1207-1612) but did not react significantly with the epitope. Low level antibody reactivity to a panel of 40 overlapping 16-mer peptides spanning residues 1207-1612 of HCV NS3 protein was observed in H-2 congenic B10 mice, leading the authors to conclude that the antigenic determinants were predominantly discontinuous or dependent on conformation.

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