T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus--positive blood donors without viremia.

Title:

T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus--positive blood donors without viremia.

Dataset

identifier:	1324214
description:	epitope description:WTTQGCNCSIYPGHITGHRMAWDMM antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	8855177

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002087
landingPage:	http://www.iedb.org/assay/1324214

Publication

type:	Literature
publicationVenue:	Hepatology
dates:	1996

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus

Person

fullName:	M Lechmann H G Ihlenfeldt I Braunschweiger G Giers G Jung B Matz R Kaiser T Sauerbruch U Spengler

Data Type

method:	ELISA

Study

name:	T- and B-cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy anti-hepatitis C virus--positive blood donors without viremia.
description:	Subjects with strong T cell responses had low or no detectable levels of peptide-specific antibodies, and vice-versa. In general, T cell responses were more common in patients who recovered from HCV infection, while B cell responses were more common in chronically infected patients. Therefore, the authors suggests that a benign course of HCV infection may be the consequence of the effective activation of T-helper lymphocytes.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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