Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo.

Title:

Dataset

identifier:	1325901
description:	epitope description:ACKQNVSSLDEKNSVSVD antigen name:Outer surface protein A host organism:Mus musculus AKR
aggregation:	instance of dataset
availability:	available
primaryPublications:	8921965

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002137
landingPage:	http://www.iedb.org/assay/1325901

Publication

type:	Literature
publicationVenue:	Eur J Immunol
dates:	1996

Dimension

study type:	b cell assays
subject species:	Borrelia burgdorferi ZS7

Person

fullName:	W Zhong K H Wiesmü ller M D Kramer R Wallich M M Simon

Data Type

method:	ELISA

Study

name:	Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo.
description:	A panel of overlapping 20mers were synthesized from the OspA sequence. Mice primed with E1 peptide were challenged on day 10 with Lip-OspA or pOspA to measure OspA-specific IgG levels. IgG was detected, however, no IgM was detected.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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