Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex.

Title:

Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex.

Dataset

identifier:	1326002
description:	epitope description:LSGRPAIVPDREVLYQEFDE antigen name:Genome polyprotein host organism:Mus musculus B10.S
aggregation:	instance of dataset
availability:	available
primaryPublications:	9367358

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002146
landingPage:	http://www.iedb.org/assay/1326002

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	1997

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1b

Person

fullName:	Z X Zhang M Chen C Hultgren A Birkett D R Milich M Sä llberg

Data Type

method:	ELISA

Study

name:	Immune responses to the hepatitis C virus NS4A protein are profoundly influenced by the combination of the viral genotype and the host major histocompatibility complex.
description:	Sera from mice immunized with the epitope's source protein, HCV NS4A, recognized the epitope by EIA. Single amino acid substitution was used to demonstrate residues 1698, 1699, and 1702 as being key in recognition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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