Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002164 |
| landingPage: |
http://www.iedb.org/assay/1326494 |
| type: |
Literature
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| publicationVenue: |
Lancet
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| dates: |
1994
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| study type: | b cell assays |
| subject species: | Streptococcus pyogenes serotype M5 |
| fullName: |
S Pruksakorn
B Currie
E Brandt
D Martin
A Galbraith
C Phornphutkul
S Hunsakunachai
A Manmontri
M F Good
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| method: |
biological activity
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| name: |
Towards a vaccine for rheumatic fever: identification of a conserved target epitope on M protein of group A streptococci.
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| description: |
Overlapping 20-mer peptides representing the conserved region (residues 145-159) of the M5 protein of S. pyogenes were synthesized to identify a broadly reactive target epitope
Bactericidal activity ranging from 79%-100% was obtained against all naturally-occurring isolates of M serotypes using the anti-peptide 145 sera. Lower inhibition was observed against some of the reference strains. Bactericidal activity correlated with the level of anti-p145 measured by ELISA.
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| name: |
iedb
|
| homePage: |
http://www.iedb.org |
