Towards a vaccine for rheumatic fever: identification of a conserved target epitope on M protein of group A streptococci.

Title:

Towards a vaccine for rheumatic fever: identification of a conserved target epitope on M protein of group A streptococci.

identifier:	1326484
description:	epitope description:SDSQTPDTKPGNKAVPGKGQ antigen name:UniProt:A2RGM0 host organism:Homo sapiens antibody name:Human sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	7520963

study type:	b cell assays
subject species:	Streptococcus pyogenes serotype M5

fullName:	S Pruksakorn B Currie E Brandt D Martin A Galbraith C Phornphutkul S Hunsakunachai A Manmontri M F Good

method:	ELISA

name:	Towards a vaccine for rheumatic fever: identification of a conserved target epitope on M protein of group A streptococci.
description:	Overlapping 20-mer peptides representing the conserved region (residues 145-159) of the M5 protein of S. pyogenes were synthesized to identify a broadly reactive target epitope. None of the subjects tested (Thais or Aborigines, heart disease or non heart disease, rheumatic or non-rheumatic) had significant serum antibody levels specific for this peptide.

name:	iedb
homePage:	http://www.iedb.org

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