T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.

Title:

Dataset

identifier:	1327043
description:	epitope description:GSTAHNARTLTGMFSLGARQK antigen name:Genome polyprotein host organism:Homo sapiens antibody name:Human sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	9886434

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1002047
landingPage:	http://www.iedb.org/assay/1327043

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	1999

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus isolate HC-J6

Person

fullName:	M Shirai M Chen M Nishioka K Ikeda H Takahashi N Enomoto M E Major T Nakazawa T Akatsuka S M Feinstone J A Berzofsky

Data Type

method:	ELISA

Study

name:	T cell recognition of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.
description:	Four synthetic peptides were generated to represent homologous sites at residues 390-410 from four different HCV isolates. Patients responded positively to peptides synthesized to share the sequence of their own HCV isolate. Only patients who showed T helper responses had detectable antibodies binding to their own isolate's sequence (p390-410).

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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